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Characteristics and outcomes of thymomas in Latin America: Results from over 10 years of experience (CLICaP-LATimus)

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dc.contributor.authorMartín, Claudio
dc.contributor.authorEnrico, Diego
dc.contributor.authorMas, Luis
dc.contributor.authorPatane, Ana Karina
dc.contributor.authorArrieta, Oscar
dc.contributor.authorSoria, Tannia
dc.contributor.authorCardona, Andres F.
dc.contributor.authorRuiz-Patiño, A.
dc.contributor.authorRuiz, Rossana
dc.contributor.authorRioja, Patricia
dc.contributor.authorLozano, Sophia
dc.contributor.authorZatarain-Barrón Zyanya Lucia
dc.contributor.authorBarrón, Feliciano
dc.contributor.authorPuparelli, Carmen
dc.contributor.authorTsou Florencia
dc.contributor.authorCorassa, Marcelo P.
dc.contributor.authorFreitas, Helano C.
dc.contributor.authorCordeiro de Lima, Vladmir Cláudio
dc.contributor.authorRojas, Leonardo
dc.contributor.authorOrdóñez-Reyes, Camila
dc.contributor.authorCorrales, Luis
dc.contributor.authorSotelo, Carolina
dc.contributor.authorRodríguez, July
dc.contributor.authorRicaurte, Luisa
dc.contributor.authorÁvila, Jenny
dc.contributor.authorArchila, Pilar
dc.contributor.authorRosell, Rafael
dc.contributor.authorCuello, Mauricio
dc.contributor.authorRemon, Jordi
dc.date.accessioned2023-06-27T12:29:32Z
dc.date.available2023-06-27T12:29:32Z
dc.date.issued2021
dc.description.abstractBackground: Thymomas are a group of rare neoplasms of the anterior mediastinum. The objective of this study was to describe the demographics, clinical characteristics and treatment approaches in Latin America. Methods: This was a retrospective multicenter cohort study including patients with histologically proven thymomas diagnosed between 1997 and 2018. Demographics, clinicopathological characteristics and therapeutic outcomes were collected locally and analyzed in a centralized manner. Results: A total of 135 patients were included. Median age at diagnosis was 53 years old (19-84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG performance score ranging from 0-1. A total of 47 patients (34.8%) had metastatic disease at diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgery was performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and 47 (34.8%) thymectomies. According to the Masaoka-Koga system, overall survival (OS) at five-years was 73.4%, 63.8% and 51%, at stages I-II, III-IVA and IVB, respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase (LDH) (≤373 IU/L) at baseline and myasthenia gravis concurrence showed significantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, high LDH levels (HR 2.8 [95% confidence interval [CI]: 1.1-7.8]; p = 0.036) at baseline and not performing a surgical resection (HR 4.1 [95% CI: 1.3-12.7]; p = 0.016) were significantly associated with increased risk of death. Conclusions: Our data provides the largest insight into the clinical characteristics and outcomes of patients with thymomas in Latin America. Survival in patients with thymomas continues to be very favorable, especially when subjected to adequate local control. Keywords: Latin America; cohort studies; medical oncology; thymoma.
dc.identifier.citationMartín C, Enrico D, Mas L, Patane AK, Arrieta O, Soria T, Cardona AF, Ruiz-Patiño A, Ruiz R, Rioja P, Lozano S, Zatarain-Barrón ZL, Barrón F, Puparelli C, Tsou F, Corassa MP, Freitas HC, Cordeiro de Lima VC, Rojas L, Ordóñez-Reyes C, Corrales L, Sotelo C, Rodríguez J, Ricaurte L, Ávila J, Archila P, Rosell R, Cuello M, Remon J; CLICaP. Characteristics and outcomes of thymomas in Latin America: Results from over 10 years of experience (CLICaP-LATimus). Thorac Cancer. 2021;12:1328–1335. https://doi.org/10.1111/1759-7714. 13901
dc.identifier.urihttp://biblioteca.solcaquito.org.ec:9997/handle/123456789/404
dc.language.isoen
dc.publisherThorac Cancer
dc.titleCharacteristics and outcomes of thymomas in Latin America: Results from over 10 years of experience (CLICaP-LATimus)
dc.typeArticle
dspace.entity.typePublication
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